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KMID : 0984720030350030138
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Infection and Chemotherapy
2003 Volume.35 No. 3 p.138 ~ p.144
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The Study of 46 Cases of Tsutsugamushi Disease in Young-Dong Region in Gang-Won-DO
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Jang Jin-Gun
Park Bae-Keun
Lee Hee-Sob
Maeng Joo-Hee
Kim Hyoun-Sung
Lee Seung-Chan
Yoon Song-Kyoo
Choi Jong-Soo
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Abstract
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Background: Although the incidence of tsutsugamushi disease has been increasing in Korea, epidemiological and clinical characteristics of tsutsugamush disease in Young dong province have not been reported.
Methods: we retrespectively reviewed the medical records of 46 patients of tsutsugamushi disease who admitted at Gangneung Asan hospital from 1997 to 2001.
Results: Incidence of tsutsugamushi disease in Young-dong province had been incrasing since 1999. Most patients were infected during agricultural work. The incidence of women was higher than that of men (65.2%). Characteristic laboratory finding was elevation of AST and ALT, hypoalbuminemia and thrombocytopenia. Despite fever, leukocytosis was found only in 20% of patients. Course of disease was relatively good in most patients, but complications such as pneumonia, acute renal failure, and shock developed in 26% of patients. In one case with acute renal failure and another case with pneumonia, the patients´ condition aggravated in spite of doxycyline therapy, thus, hemodialysis and mechanical ventilator care were done respectively. Consequently, both patients recovered completely without chronic complication. Old age (>65 years), longer duration from onset of symptoms to admission (>10 days), hypoalbuminemia at admission(<2.6 g/dL) and leukocytosis could be used as a marker for prediction of complication.
Conclusion: Incidence of tsutsugamush disease increased in Young dong region. Old age, delayed admission, hypoalbuminemia and leukocytosis could be used as marker for prediction of complications.
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KEYWORD
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tsutsugamushi, complication, young dong
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